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News

The Duality of Skin Oxygen: Balancing Vitality and Damage

September 09, 2024

Oxygen is essential for life, but it also has a complex and sometimes harmful relationship with our skin. At Luksha Cosmetics, we embrace this dual role by developing products that enhance skin health while protecting against oxidative stress. Our commitment to the latest research allows us to harness oxygen’s benefits while mitigating its risks.

Oxygen: Essential Yet Complex

Oxygen (O₂), commonly referred to as dioxygen, is a molecule composed of two oxygen atoms and is essential for the survival of all aerobic organisms. While it is widely known for its critical role in generating cellular energy in the form of ATP through the mitochondrial respiratory chain, oxygen is also crucial for numerous physiological functions and biochemical processes. It participates in cell signaling, regulates vascular tone and gene expression, and contributes to the body's antimicrobial defense mechanisms.

Despite the fact that ambient air contains approximately 21% oxygen (160 mm Hg), oxygen concentrations within different organs are significantly lower. These levels are finely tuned to match each organ’s vascularization, function, metabolism, and energy demands. This is especially true for the skin, which displays distinct oxygen concentration gradients.

Skin Physioxia: The Importance of Oxygen Gradients

Physioxia, introduced by Carreau et al. in 2011, describes the partial oxygen pressure in an organ under normal physiological conditions. Unlike atmospheric normoxia (21% oxygen) or pathological hypoxia, this term offers a more accurate view of oxygen levels in the body.
In the dermis, oxygen levels are around 7%, while in the non-vascularized epidermis, they drop to between 1% and 3%. The highest concentration is found in the stratum corneum (direct contact with the air), with just 1% in the basal layer. This oxygen gradient plays a key role in skin health, regulating processes like stem cell maintenance and keratinocyte differentiation.


Physioxia stimulates strong proliferation of keratinocytes, both in monolayers and in reconstructed human epidermis (RHE), resulting in a thinner epidermis. This effect is likely due to a slowdown in the terminal differentiation of keratinocytes. Additionally, under physioxic conditions, cells exhibited a reduced production of reactive oxygen species (ROS) in response to stress, indicating enhanced protection against oxidative stress. This is likely due to the increased activity of superoxide dismutase 2 (SOD2). These findings offer a groundbreaking perspective on the interaction between oxygen and the skin, highlighting the importance of mimicking realistic physiological conditions in dermocosmetic research, particularly in the development of active ingredients designed to combat oxidative stress.

Oxidative Stress and Aging

Oxygen, while essential for life, has a dual role in tissue health. Though vital, it can also be harmful by contributing to the production and accumulation of reactive oxygen species (ROS), which damage cell components like proteins, lipids, and DNA. These ROS, formed as by-products of oxygen metabolism, include both radical and non-radical species and are produced within various cell compartments or triggered by external factors such as UV exposure, pollution, smoking, stress, lack of sleep, and lifestyle choices.

Oxidative stress occurs when there is an imbalance—too many ROS and an overwhelmed antioxidant system unable to neutralize them. This imbalance is a key driver of aging, a theory first proposed by Denham Harman in 1956, known as the "Free Radical Theory of Aging." Additionally, ROS influence cell signaling pathways like MAPK and NF-kB, which, when overactivated, trigger the production of matrix metalloproteinases (MMPs) responsible for breaking down the extracellular matrix (ECM), leading to "inflammaging." This process is particularly evident in photoaging, where overexpression of MMP-1, MMP-3, and MMP-9 accelerates skin aging.

While UV exposure is a well-known cause of extrinsic skin aging, other factors like visible light, infrared radiation, and pollutants also play a significant role in premature aging. As a result, industry experts are working to develop solutions that protect the skin from these environmental stressors.

Luksha Cosmetics’ Innovative Approaches

At Luksha Cosmetics, we have adopted several advanced strategies to counteract the harmful effects of oxygen while promoting its skin health benefits.

1. Contouring Multi-Action Cream

Our Contouring Multi-Action Cream is a standout example of how we combine cutting-edge science with effective skincare solutions. This cream is packed with powerful antioxidants to combat oxidative stress, featuring:

- Coenzyme Q10: A powerful antioxidant that protects the skin from environmental damage while reducing the appearance of fine lines and wrinkles. It also supports natural collagen production, improving skin firmness and elasticity.

- Tetrahexyldecyl Ascorbate: A stable, oil-soluble form of Vitamin C known for its outstanding antioxidant and skin-brightening properties. 

- Vitamin E: Another potent antioxidant that protects the skin from free radical damage, aids in skin repair, and supports the skin barrier, making the skin appear healthier and more youthful.

The combination of these ingredients makes the Contouring Multi-Action Cream a powerful tool in defending against the harmful effects of oxidative stress while promoting a more youthful and firm complexion.

2. Nourishing Cream

Our Nourishing Cream blends antioxidants like Raspberry Seed Oil and Vitamin E to fight oxidative damage and improve skin repair. This cream helps improve skin tone and shield the skin from environmental stressors, ensuring a radiant and youthful look.

3. Eco-Balance Probiotic Night Cream

This cream reduces oxidative stress by strengthening and supporting the skin’s microbiome, helping to promote a healthier, more balanced complexion. 

4. Moisturizing Cream-Mask

This product boasts a powerful form of Vitamin E that not only combats oxidative stress but also delivers intense hydration, leaving your skin nourished, protected, and radiant.

The Future of Skincare and Oxygen

At Luksha Cosmetics, we understand the dual role of oxygen in skin health, and our goal is to develop products that both leverage its benefits and protect against its potential harm. By incorporating antioxidants and respecting the skin’s natural oxygen gradient, we create solutions that not only improve skin health but also prevent premature aging.

As research evolves, at Luksha Cosmetics will continue to offer advanced, targeted skincare solutions that respect the balance of oxygen in the skin, ensuring our clients experience the best in both protection and skin vitality.

References:

  1. Hancock, J. T. Oxygen 1, 3-15 (2021).
  2. Carreau, A., et al. J Cell Mol Med 15, 1239-1253 (2011).
  3. Grillon, C., et al. Experimental Dermatology 21, 723-728 (2012).
  4. Chettouh Hammas, N. Influence du taux d'oxygénation et du photovieillissement sur l'activité antioxydante des cellules de la peau. (Orléans, 2022).
  5. Chettouh-Hammas, N. et al. Oxid Med Cell Longev 2023, 6829931 (2023).

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The Science of Skin-Lightening Skincare

July 20, 2024

Introduction

Have you ever wondered why your skin looks the way it does? Skin pigmentation and color vary widely, influenced by genetics, geographical location, and sun exposure. While the idea of the perfect skin tone has evolved over time, many people still seek that radiant, even complexion. From ancient beauty rituals to modern skincare routines, the quest for luminous skin has always been a fascinating journey.

Understanding Skin Pigmentation

So, what gives our skin its color? The magic lies in melanin, the pigment produced by melanocytes. There are two types of melanin: eumelanin (which gives black and brown hues) and pheomelanin (which adds red and yellow tones). The balance of these pigments determines our unique skin and hair colors. The key player in this process is the enzyme tyrosinase, which converts L-tyrosine to L-DOPAquinone, leading to the production of melanin. Tyrosinase is the key enzyme that determines the pigmentation of the skin and the intensity of pigment spots.

The Quest for Skin-Friendly Lightening Ingredients

The cosmetic industry has long been on the hunt for the perfect skin-lightening ingredients. The goal? To find compounds that not only lighten skin effectively but also do so without causing irritation. This has led to the exploration of many ingredients, some of which have proven effective but come with restrictions due to their potential side effects. The exciting news is that new, skin-friendly options are emerging, thanks to advances in science and technology.

Meet N-Acetylglucosamine (NAG)

One of the standout ingredients in the world of skin lightening is N-Acetylglucosamine (NAG). This little powerhouse is a monosaccharide derived from glucose and chitin, which is naturally found in the shells of crustaceans. What makes NAG so special? It inhibits the conversion of protyrosinase to tyrosinase, effectively reducing pigmentation.

In an impressive 8-week split-face study, a combination of 2% NAG and 4% niacinamide (another skincare superstar) reduced pigmentation by 30%. Niacinamide helps by preventing melanosomes (pigment packets) from transferring to skin cells, enhancing the lightening effect.

Discover the Power of Luksha’s Intensive Hydrating Serum

Here at Luksha, we believe in combining the best of science and nature to create products that make you feel amazing. Our Intensive Hydrating Serum is a perfect example. It features not only the powerful humectant Hyaluronic Acid—both Medium and Super Low Molecular—but also skin-lightening, skin-friendly components like NAG and niacinamide. This serum works wonders by hydrating deeply and helping to even out skin tone, giving you that coveted glow.

Conclusion

The journey to finding effective and gentle skin-lightening ingredients is an ongoing adventure. With the help of innovative ingredients like NAG and the benefits of niacinamide, we can create products that enhance your skin's natural beauty. At Luksha, we're committed to developing skincare solutions that not only meet your needs but also inspire confidence and joy.

So, whether you're looking to brighten your complexion or simply want to learn more about the magic behind your skincare, remember that every product has a story. And at Luksha, that story is all about celebrating the beauty and uniqueness of your skin.

By understanding how these ingredients work and incorporating them into your routine, you can achieve a healthier, more radiant complexion. Dive into the world of skincare with us, and discover the difference that thoughtful, scientifically-backed products can make.

References:

1. Del Bino S, Duval C, Bernerd F. Clinical and Biological Characterization of Skin Pigmentation Diversity and Its Consequences on UV Impact. Int J Mol Sci 2018, 19.

2. Jablonski NG, Chaplin G. Colloquium paper: human skin pigmentation as an adaptation to UV radiation. Proc Natl Acad Sci US A 2010, 107 Suppl 2: 8962-8968.

3. Mann T, Gerwat W, Batzer J, Eggers K, Scherner C, Wenck H, et al. Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase. Journal of Investigative Dermatology 2018, 138: 1601-1608.

4. Jin YH, Lee SJ, Chung MH, Park JH, Park YI, Cho TH, et al. Aloesin and arbutin inhibit tyrosinase activity in a synergistic manner via a different action mechanism. Archives of pharmacal research 1999, 22: 232-236.

5. Nokinsee D, Shank L, Lee VS, Nimmanpipug P. Estimation of Inhibitory Effect against Tyrosinase Activity through Homology Modeling and Molecular Docking. Enzyme Res 2015, 2015: 262364.

6. Wang Z, Xiang H, Dong P, Zhang T, Lu C, Jin T, et a/. Pegylated azelaic acid: Synthe-sis, tyrosinase inhibitory activity, antibacterial activity and cytotoxic studies. Journal of Molecular Structure 2021, 1224: 129234.

7. Jirawattanapong W, Saifah E, Patarapanich C. Synthesis of glabridin derivatives as tyrosinase inhibitors. Arch Pharm Res 2009, 32: 647-654.

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Skin Dysbiosis: Microbiota Diversity and Its Impact on Skin Health

July 09, 2024

The skin microbiota, an invisible ecosystem of living microorganisms on our skin’s surface, plays a crucial role in maintaining skin health. This bacterial community not only protects our skin from external damage but also interacts with it to ensure proper functioning. When the microbiota is balanced, a condition known as eubiosis is achieved, which is essential for healthy, beautiful skin.

However, various exposome factors, such as overexposure to UV radiation, pollution, and urban lifestyle habits, can disrupt this balance, leading to a state called dysbiosis. Dysbiosis is characterized by an imbalance in the microbial composition, distribution, and metabolic activity on the skin. This imbalance is often observed in skin disorders like atopic dermatitis, acne, and seborrheic dermatitis.

Key Microbiota Species and Their Roles

✔︎ Cutibacterium acnes (C. acnes): Dominating up to 90% of the microbiome in sebum-rich areas like the face and scalp, C. acnes is linked to conditions like acne. A loss of diversity in its phylotypes can lead to exacerbated acne, increased lipogenesis, comedone formation, and inflammation. Certain phylotypes of C. acnes, particularly phylotype lAl, are associated with a more virulent profile in acne-prone skin.

✔︎ Staphylococcus aureus (S. aureus): Known as an opportunistic pathogen, increased populations of S. aureus are related to inflammation, irritation, and conditions like acne, psoriasis, and chronic wounds.

✔︎ Staphylococcus epidermidis (S. epidermidis): This species is a major representative of a healthy skin microbiome and is present across all skin types. It plays a significant role in maintaining an effective skin barrier, wound healing, pathogen defense, immune system modulation, and melanoma prevention.

Prebiotics and Postbiotics: Balancing the Microbiome

Prebiotics, non-digestible food ingredients, stimulate the growth and activity of beneficial microbiota. They are primarily plant-based sugar molecules and oils.

Postbiotics are soluble factors, including products or metabolic byproducts secreted by live bacteria or released after bacterial lysis. These include enzymes, peptides, polysaccharides, cell surface proteins, and organic acids.

Active ingredients and products containing prebiotics and postbiotics can help improve skin conditions by balancing the microbiome. For instance, the Eco-Balance Line by Luksha Cosmetics, formulated specifically for improving the skin microbiome, includes both prebiotics and postbiotics in its science-backed formulas. Topical formulas like these often modulate the skin microbiome by their antibacterial activity against C. acnes and S. aureus, significantly impacting skin health and beauty.

Dysbiosis and Acne-Prone Skin

In acne-prone skin, dysbiosis can lead to the overproduction of sebum, enlarged pores, and worsened acne lesions, redness, and inflammation. The Eco-Balance Blemish Defence Serum by Luksha Cosmetics, featuring Phages and Niacinamide, quickly and effectively improves acne conditions by naturally modulating the skin microbiome with skin-friendly components. 

     In conclusion, understanding the balance of the skin microbiota and utilizing prebiotics and postbiotics can significantly improve skin health, offering promising avenues for treating and managing various skin disorders. The Eco-Balance Line by Luksha Cosmetics exemplifies this approach, providing effective solutions for achieving and maintaining a healthy skin microbiome.

References: 

  1.   Mühlenbruch M, Grossart H-P, Eigemann F, Voss M. Mini-review: Phytoplankton-derived polysaccharides in the marine environment and their interactions with heterotrophic bacteria. Environmental Microbiology. 2018;20(8), 2671-2685
  2.   Gueniche A, Perin, O, Bouslimani A, Landemaine L, Misra N, Cupferman S, Aguilar L, Clavaud C, Chopra T, Khodr A. Advances in Microbiome-Derived Solutions and Methodologies are Founding a New Era in Skin Health and Care. Pathogens. 2022; 11, 121
  3.   Wei Z, Ju Q. Acne and Environmental Factors. In: Acne. Springer International Publishing. 2021; p. 121-9
  4. Dreno B, Dagnelie MA, Khammari A, Corvec (2020). The skin microbiome: A new actor in inflammatory acne. American Journal of Clinical Dermatology. 2020; 21(51), 18-24
  5. Aguilar-Toala JE, Garcia-Varela R, Garcia HS, Mata-Haro V, Gonzalez-Cordova AF, Vallejo-Cordoba B, Hernandez-Mendoza A. Postbiotics: An evolving term within the functional foods field. Trends in Food Science & Technology. 2018; 75, 105-114
  6. Polak K, Jobbagy A, Muszynski T, Wojciechowska K, Fratczak A, Banvölgyi A, Bergler-Czop B, Kiss N. Microbiome Modulation as a Therapeutic Approach in Chronic Skin Diseases. Biomedicines. 2021; 9,1436
  7. Chello C, Conforti C, Dianzani C. Acne Supplementation: Probiotics, Vitamins, and Diet. Acta Dermatovenerologica Croatica. 2021; Nov; 29(4):215-223
  8. Roh M, Han M, Kim D, Chung K. Sebum output as a factor contributing to the size of facial pores: Factors related to enlarged  pores. British Journal of Dermatology. 2006;155(5), 890-894

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The Science Behind Summer Skincare: Why Your Skin Needs Special Care in the Sun

June 24, 2024

As the sun-drenched days of summer beckon, our skin faces a unique set of challenges. While the warmth and brightness uplift our spirits, they also demand a tailored approach to skincare. Here’s why special skincare is essential during the summer months and how it can make a profound difference to your skin’s health and appearance.

The Summer Skin Challenge

1. Increased UV Exposure:
The most obvious threat during summer is the increased exposure to ultraviolet (UV) radiation. Prolonged UV exposure can lead to sunburn, premature aging, and an elevated risk of skin cancer. UV rays penetrate deep into the skin, causing DNA damage in skin cells and breaking down collagen, which results in wrinkles and loss of skin elasticity.

2. Dehydration and Moisture Loss:
High temperatures and increased sweating can lead to significant moisture loss. The skin’s natural barrier can become compromised, leading to dehydration. When the skin is dehydrated, it appears dull, feels tight, and is more susceptible to irritation and further damage.

3. Compromised Lipid Barrier:
During summer, the skin’s lipid barrier can become compromised due to factors such as increased water activity (swimming), sweating, and frequent sunscreen application and removal. This lipid barrier is crucial for maintaining skin hydration and protecting against external irritants. When disrupted, it can lead to increased transepidermal water loss (TEWL), making the skin more vulnerable to dryness, irritation, and environmental damage.

4. Excess Sebum Production:
Heat and humidity can stimulate the sebaceous glands, causing them to produce more oil. This excess sebum can clog pores, leading to breakouts and an uneven skin texture.

5. Environmental Pollutants:
Summer activities often expose us to increased environmental pollutants. These pollutants can generate free radicals, which cause oxidative stress and inflammation, further damaging the skin.

The Importance of Diligent Skin Care During the Hotter Months

Skin acts as a barrier against harmful external and internal factors. Solar ultraviolet radiation (UVR) is a major risk, causing acute and chronic skin damage, including sunburn, premature aging, and skin cancer. Overexposure to UVR, especially for outdoor workers and indoor tanning enthusiasts, increases the risk of skin diseases.

Sunburn results in erythema, increased melanin, and keratinocyte apoptosis, potentially leading to skin carcinoma. UVR-induced molecular and pigmentary changes can cause long-lasting pigmentation and immunosuppressive skin diseases.

Given these dangers, diligent skincare during the hotter months is essential to protect and maintain skin health. Using scientifically-backed skincare routines helps shield your skin from UVR's harmful effects, keeping it resilient and radiant throughout the summer.

When to Apply After-Sun

If your skin has been exposed to the sun, you should apply an after-sun cream as frequently as needed to keep your skin adequately moisturized to avoid peeling. Overexposure to UV radiation may result in sunburn or erythema. If your skin looks blotchy and is hot to the touch, you’ve probably spent too much time in the sun. Other symptoms of overexposure include blistering, peeling skin, and itching. Applying an after-sun cream can help relieve pain and decrease inflammation. However, if the sunburn is severe and becomes too painful, you should consult a doctor for adequate medical treatment.

Luksha Cosmetics: The Science of Summer Skincare

To combat these challenges, a scientifically-backed skincare routine tailored for summer is crucial. Here’s how Luksha Cosmetics products and ingredients work together to protect and rejuvenate your skin.

1. Cleansing with Care:
A gentle Cleansing Oil with Organic Clove Stem Oil and Vitamin E, effectively removes sunscreen, makeup, and impurities without stripping away the skin’s natural lipids. This maintains the skin’s moisture balance while preparing it for further treatment. 

2. Restoring pH Balance:
Toner with Organic Rose Water, Organic Cranberry Extract, and Organic Aloe Leaf Juice can refresh and calm the skin, restoring its natural pH. This step is vital for maintaining the skin’s barrier function and preventing irritation.

3. Deep Hydration:
Hydration is paramount during summer. An Intensive Hydrating Serum with Edelweiss, Hyaluronic Acid, and Provitamin B5 provides deep hydration, helping to replenish the moisture lost due to heat and sun exposure. Hyaluronic Acid, in particular, is a powerful humectant that draws moisture into the skin, improving its elasticity and texture.

4. Balancing and Protecting:
Daytime protection is enhanced with Eco-Balance Probiotic Radiance Cream with Pomegranate Seed Oil and Coenzyme Q10. This formulation not only balances the skin’s microbiome but also provides antioxidants that protect against free radical damage. Coenzyme Q10, a potent antioxidant, helps to neutralize free radicals and prevent oxidative stress. Crafted with a multi-lamellar structure, Eco-Balance Probiotic Radiance Cream mirrors skin lipids, immediately restoring the skin's natural barrier and promoting optimal skin health.

5. Nighttime Repair:
At night, a Moisturizing Cream-Mask with Hyaluronic Acid and Shea Butter can work wonders. This rich formulation restores and smooths the skin, promoting repair and rejuvenation while you sleep. Shea Butter provides deep nourishment, while Hyaluronic Acid ensures continuous hydration. Designed with a multi-lamellar structure, Moisturizing Cream-Mask mimics skin lipids, instantly restoring the skin's natural barrier and enhancing overall skin health.

☀️ Enjoy all these exceptional products together in our After-Sun Care Set, now available at a special price!

Summer Tip:  For an immediate cooling effect, consider storing your after-sun skincare products in the refrigerator.

Using After-Sun Beyond Summer

An after-sun cream doesn’t have to be used just to treat sunburn. Compared to standard moisturizers, after-sun products contain additional soothing ingredients, making them suitable for use whenever your skin feels tight and dry, even during winter months. After-sun formulas typically have a lightweight texture to ensure that heat doesn’t stay trapped inside the skin, making them perfect for daily use. It’s a highly versatile product that helps maintain your skin's smoothness and hydration all year round.

In essence, summer skincare is not just about addressing the immediate effects of sun exposure but also about preventive care that maintains and enhances skin health. By incorporating products that cleanse gently, hydrate deeply, balance, and protect, you can ensure your skin remains resilient and radiant throughout the sunny months. Embrace the science of summer skincare and let your skin glow with health and vitality, no matter how high the mercury rises.

Your skin deserves the best care year-round! Embrace the science of summer skincare and let your skin glow with health and vitality. Explore Luksha After-Sun Care Set at a special discounted price and give your skin the nourishment and protection it deserves. Start your journey to healthier, radiant skin today!

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Ever wondered why your skincare routine needs a unique approach throughout the year? Discover how Luksha Cosmetics Cleansing Oil can transform your skin in every season.

June 20, 2024

Throughout the year, skincare must be both effective and gentle, removing makeup, sunscreen, and environmental impurities without compromising the skin barrier. This is especially true for mature or thin skin. The scientifically developed formula of Luksha Cosmetics Cleansing Oil excels in maintaining this balance, no matter the season.

Many individuals with oily skin mistakenly reach for harsh "grease-cutting" products like gels or soaps, which disrupt the skin's natural barrier. This leads to over-drying and triggers an overproduction of sebum, resulting in a cycle of tight, dehydrated skin followed by excessive oiliness. Using the correct cleansing method, like our oil-based formula, breaks this cycle, ensuring balanced sebum production.

Year-round sunscreen use is essential, but its water-resistant formulation can make it challenging to remove effectively. Luksha Cosmetics Cleansing Oil breaks down sunscreen residue thoroughly, ensuring that the skin is properly cleansed to avoid clogged pores and to rejuvenate overnight. Oil cleansing is supported by scientific research—lipophilic molecules in oil bind to sebum and impurities, dissolving them without compromising the skin’s lipid barrier, which is critical across different seasons.

Our Cleansing Oil features an advanced, scientifically backed formulation using Rice Bran Oil, which employs the "sacrifice lipid" principle—adding lightweight, skin-identical lipids that emulsify impurities. Combined with ultra-gentle surfactants, our formula keeps your natural lipids intact while preserving the skin’s slightly acidic pH, thus enhancing overall skin health. This is especially crucial during times of increased environmental stress, whether due to summer UV exposure, winter dryness, or pollutants.

The natural formulation of our Cleansing Oil also includes rice bran oil—rich in Coenzyme Q10—and Vitamin E, providing both cleansing and nourishment with potent antioxidants that promote skin health. Properly cleansed skin maintains a balanced pH, healthy lipid barrier, and optimal hydration, leading to radiant, resilient skin all year long.

Beauty professionals agree that cleansing with oil is the optimal way to maintain skin health. Luksha Cosmetics Cleansing Oil effectively dissolves excess sebum, removes impurities, and supports the skin's lipid balance, helping the skin stay hydrated and healthy through all seasons.

Our Cleansing Oil is available as part of a Facial Cleansing Set at a reduced price—making year-round skin health even more accessible.

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The Rise of Psycho-Dermatology in the Cosmetics Industry

June 11, 2024

The Rise of Psycho-Dermatology in the Cosmetics Industry

Psycho-dermatology is an emerging field that highlights the intricate connection between the mind and the skin. It explores how mental well-being, particularly factors like anxiety, depression, stress, and elevated cortisol levels, can significantly impact the skin. For instance, conditions such as skin irritation, dryness, and acne are often linked to mental health issues. Conversely, skin problems can exacerbate mental health conditions, creating a vicious cycle. In the cosmetics industry, psycho-dermatology focuses on how personal care products and ingredients can improve skin appearance by addressing this mind-skin connection.

The prominence of psycho-dermatology has surged in recent years for two main reasons. Firstly, there has been a notable rise in mental health issues within society, and the increased dialogue around these topics has underscored their impact on various aspects of life, including skin health. This recognition comes from medical professionals, researchers, and journalists rather than cosmetic brands alone. Secondly, it remains challenging for cosmetic brands to make claims about products' effects on mental well-being due to stringent regulations. Despite having ingredients with proven efficacy in demonstrating the mind-skin connection, brands must navigate these claims carefully to avoid regulatory breaches. The growing awareness of psycho-dermatology has made it easier to link relaxation and self-care with improved skin appearance without overstepping these boundaries.

Common Psychocutaneous Disorders

Psychocutaneous disorders can manifest in several ways, with common symptoms associated with the body's fight-or-flight response, such as skin redness and increased perspiration. Chronic stress can exacerbate conditions like acne, especially in teens and adults, and lead to heightened skin sensitivity, dryness, and collagen degradation, which accelerates aging. Additionally, stress-related conditions such as psoriasis, urticaria, and dermatitis can arise, though these require medical rather than cosmetic intervention.

Collaboration Between Mental Health Professionals and Dermatologists

Integrating mental health support with dermatological care can significantly enhance customers outcomes. By acknowledging and explaining the mind-skin connection, healthcare providers can offer patients a holistic approach to treatment, providing hope and a pathway to improved appearance and well-being. When customers see positive changes in their skin, it can boost their self-esteem and overall mental health, creating a positive feedback loop.

Cosmetics Companies and Psycho-Dermatology

Cosmetic companies play a crucial role in the psycho-dermatology landscape by developing skincare products with active ingredients that address the physical effects of stress and anxiety on the skin. These products not only improve the skin's appearance but also enhance the user's self-assessment and well-being. 

Recommended Active Ingredients and Technologies

At Luksha Cosmetics, we integrate cutting-edge scientific advancements and carefully selected active ingredients to address psycho-dermatology concerns effectively. Our formulations feature skin-identical ingredients and a unique skin-identical water-lipid membrane lotion structure known as lamellar structure, which provides immediate comfort to the skin.

Some of the key active ingredients we use include:

  • Organic Rose Otto Flower Oil: This ingredient, included in our Toner, Nourishing Cream, and Moisturizing Cream-Mask, is renowned for its soothing and hydrating properties, offering a calming effect on stressed skin and mind.

  • Lactococcus Ferment Lysate: Found in our Eco-Balance Line, this probiotic-derived ingredient helps to balance the skin's microbiome, enhancing its natural defenses and promoting healthier skin.

  • Saccharide Isomerate: Present in our Eco-Balance Prebiotic Serum, this prebiotic ingredient nourishes beneficial skin bacteria, promoting a balanced microbiome and healthy skin. It enhances hydration, supports the skin's natural barrier, and has potential anti-inflammatory properties, contributing to overall skin health and resilience.

  • Aloe Barbadensis Leaf Extract: Also included in our Eco-Balance Prebiotic Serum, this extract soothes and hydrates the skin, reducing inflammation and promoting healing.

  • Allantoin: Found in our Moisturizing Cream-Mask and Eco-Balance Probiotic Night Cream, it is known for its exceptional skin-soothing and hydrating properties. Allantoin is ideal for calming irritated or sensitive skin, aiding in the skin's natural healing processes, reducing redness, and leaving the skin smoother and more comfortable.

These scientifically-backed ingredients, combined with our innovative lamellar structure technology, ensure that our skincare products not only improve the appearance of the skin but also provide an immediate sense of relief and comfort, addressing both physical and psychological aspects of skin health. Through these advanced formulations, Luksha Cosmetics is committed to enhancing overall well-being by recognizing and supporting the mind-skin connection.

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Interesting Facts About Sunscreens You Might Not Be Aware Of

June 03, 2024

  1. Broad-Spectrum Coverage: Protecting your skin from the sun isn't just about sunscreen. Sun-protective clothing, like hats, sunglasses, and UV-blocking shirts, can be even more effective. It's a great idea to mix and match for the best protection!

 

2. SPF Application: Did you know that the SPF number on your sunscreen is based on applying 2ml per square cm of skin? That’s roughly one teaspoon for your face. So, if you’re applying a thin layer of SPF 50, you might actually be getting closer to SPF 20. Always apply generously and remember to reapply every two hours, especially after swimming or sweating. And remember, the main rule of any sunscreen is: Apply, Re-apply, and Re-apply. 

3. Proper Application: When applying sunscreen, don't rub it in too much. Your skin has folds and textures that need full coverage. Ensure you cover every part of your face and body evenly for maximum protection.



4. Types of Sunscreen Filters: Sunscreens use different types of filters to protect against UV radiation. Physical filters like Zinc Oxide (ZnO) and Titanium Dioxide (TiO2) are generally recognized as safe (GRAS). Chemical filters, such as Avobenzone and Octinoxate, are often more effective and require less product for the same level of protection.

5. Systemic Absorption: Studies have shown that if you use the maximum amount of chemical UV filters (2ml per square cm of skin, for 75% of your body, four times a day), systemic absorption can exceed safe levels. To minimize this, you might choose to use sunscreen mainly on your face and cover your body with sun-protective clothing.

6. Absorption vs. Reflection: It's a common belief that mineral sunscreens work by reflecting UV rays. However, both organic and inorganic sunscreen particles primarily absorb UV radiation. Understanding this helps in choosing the right product for effective protection.

7. Unlisted Organic Filters: It's good to know that some sunscreens might contain chemical filters even if they are labeled as mineral-only. These chemical filters might not be officially registered as UV filters, so they aren’t listed on the product, but they still provide protection. Examples of not registered UV chemical filters: Ethylhexyl Methoxycrylene, Butyloctyl Salicylate.

8. Removing Sunscreen: Sunscreens are designed to be long-lasting and can be difficult to remove. It's essential to thoroughly cleanse your skin at the end of the day to prevent clogging pores and other skin issues. We recommend using Luksha Cosmetics' gentle and super effective oil-based cleanser, Cleansing Oil with Organic Clove Stem Oil and Vitamin E, to remove all traces of sunscreen and keep your skin healthy. Its also available in the Facial Cleansing Set, pairing with a Toner. 

9. Environmental Impact: Concerns have been raised about the environmental impact of sunscreen ingredients, particularly on coral reefs. However, current data suggests that UV filters are not a major factor affecting coral health compared to climate change, agricultural pollution, over-fishing, and recreational activities. Still, it's good to be mindful of the products you use, especially if you spend a lot of time in the ocean.

By knowing these facts, you can make smarter choices about your sun protection routine and keep your skin healthy and safe from harmful UV rays.

✅ Don't forget to subscribe to our newsletter to stay informed about new articles and important skincare tips!

References:
1. Article: “Metal oxide sunscreens protect skin by absorption, not by reflection or scattering.” 
Curtis Cole, Thomas Shyr, Hao Ou-Yang, October 2015 Photodermatology Photoimmunology and Photomedicine.

2. Article: “Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients”. A randomized clinical trial. Murali K Matta, PhD, Jeffry Florian, PhD, Robbert Zusterzeet, MD, PhD, MPH. January 21, 2020

3. Burns&Davis (2021) Environmental Toxicology & Chemistry. 40(12):3441-3464.

4. Clinical and Experimental Dermatology. "A qualitative review of misinformation and conspiracy theories in skin cancer." Cathal O`Connor, Siobhan Raffery, Michelle Murphy.

5. U.S. Environmental Protection Agency

 







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Understanding Bacteriophages for Skin Health

May 26, 2024

Introduction to Bacteriophages

Modern skincare has embraced scientific advancements detailing the human microbiome’s considerable impact on overall skin health. The term "skin microbiome" refers to the collection of genomes from all the microbes residing on and inside the skin. These microbes, collectively known as the "skin microbiota," predominantly consist of commensals—organisms that colonize another organism without causing harm. These commensals can even prevent the invasion of pathogenic microbes. While most research has focused on traditional bacteria, viral components, particularly bacteriophages, are gaining attention for their significant presence and potential benefits.

The Role of Bacteriophages in Skincare

Bacteriophages, or simply "phages," are viruses that exclusively infect and propagate within bacterial cells. They play a crucial role in balancing the microbiome of blemish-prone skin. Phages propagate through either the lytic or lysogenic cycle. In the lytic cycle, phages infect a bacterial cell, replicate, and ultimately burst the cell, releasing new phage particles to continue the cycle. The lysogenic cycle, on the other hand, involves phages integrating their genetic material into the host cell's genome, remaining dormant until activated. For skincare applications, the lytic cycle is preferred due to its immediate bactericidal effect.

Historical Context and Modern Applications

Phage therapy, which utilizes bacteriophages to treat bacterial infections, predates antibiotics and was initially developed during World War I. Although largely abandoned with the advent of antibiotics, phage therapy persisted in the former Soviet Union and has seen a resurgence due to rising antibiotic resistance. In the United States, phages are now widely used in antimicrobial food sprays to prevent foodborne illnesses, and they are classified as "generally recognized as safe" (GRAS) by regulatory agencies.

The cosmetic industry has begun to explore phage technology for its potential to modulate the skin microbiome. Phages offer a targeted approach, specifically eliminating harmful bacteria without disturbing beneficial commensals. This precision makes phages particularly advantageous over traditional antibiotics, which indiscriminately kill both harmful and beneficial microbes.

Addressing Problematic Bacteria

Cutibacterium acnes (C. acnes) is a key bacterium implicated in acne vulgaris (AV). While C. acnes is a normal and typically harmless component of the skin microbiota, certain strains can contribute to acne. These pathogenic strains often exhibit antibiotic resistance and produce virulence factors that promote inflammation and blemishes. Additionally, C. acnes can form biofilms within the pilosebaceous glands, exacerbating acne by protecting the bacteria from immune responses and treatments.

A reduction in the natural phages that target C. acnes is hypothesized to contribute to acne development. Thus, topical treatments containing C. acnes-specific phages could help restore a healthy skin microbiome by reducing pathogenic bacteria.

Luksha Phage Blend in Eco-Balance Blemish Defence Serum

Luksha Phage Blend is a potent combination of natural bacteriophages specifically targeted to C. acnes. This blend utilizes a triple phage formula of lytic bacteriophages, developed through collaboration with phage research teams to identify unique phages that efficiently propagate via the lytic cycle. Each phage in the blend was selected for its safety and effectiveness, characterized by advanced genomic and structural analyses.

The phages in Luksha Phage Blend belong to the Siphoviridae family, known for their ability to target C. acnes. Genomic sequencing confirmed the uniqueness of each phage, ensuring robust efficacy. By combining multiple phages, the blend reduces the likelihood of bacterial resistance, providing a reliable solution for managing blemish-prone skin.

Luksha Phage Blend Efficacy (Eco-Balance Blemish Defence Serum)

The efficacy of Luksha Phage Blend has been demonstrated through several key findings:

  1. Reduction of C. acnes Growth: The blend significantly reduces the growth of C. acnes.
  2. Reduction of Biofilm-Resident C. acnes: It effectively diminishes C. acnes populations residing within protective biofilms.
  3. Non-Cytotoxic to Human Skin Cells: Extensive testing has shown that the individual phages in Luksha Phage Blend do not harm human skin cells because of millions of years of evolutionary separation between phages and human viruses.
  4. Reduction of Inflammatory Signaling Molecules: The blend helps decrease the production of molecules that signal inflammation, which is crucial for managing skin health.
  5. Reduction of Sebum Production: It also reduces sebum production, addressing one of the key factors in acne development.
  6. Reduction of IL-8 Production: The blend lowers the levels of IL-8, a major inflammatory mediator associated with acne flare-ups.
  7. Targeted Action: Luksha Phage Blend precisely targets C. acnes without negatively impacting other members of the skin microbiome. In trials, it reduced C. acnes measurements by 25% after seven days of twice-daily use.

Conclusion

As consumers become more aware of the importance of microbiome balance for skin health, the demand for targeted microbiome modulators like bacteriophages will continue to grow. Bacteriophage-based approaches offer a natural and effective method to manage specific skin conditions, promoting a balanced and healthy skin microbiome. Luksha Phage Blend represents a cutting-edge innovation in this field, harnessing the power of nature to support clear and healthy skin.

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The Hidden Hero of Your Skin: Cutibacterium acnes

May 20, 2024

In the world of skincare, Cutibacterium acnes (C. acnes) often gets a bad rap. Historically labeled as a villain in the fight against acne, recent advances in science tell a different story. Thanks to cutting-edge sequencing technologies, we're peeling back the layers of this misunderstood bacterium and uncovering its surprising benefits for our skin.

The Marvel of Microbial Diversity

Imagine your skin as a bustling city, teeming with a diverse population of microbes, each playing a unique role in maintaining harmony. Among these residents, C. acnes stands out with its high strain diversity. Deep sequencing has revealed three distinct subspecies and six main phylotypes, each with unique genetic and morphological traits. This diversity is not just fascinating; it's crucial for understanding the skin's health dynamics.

Research shows that skin issues often stem from an imbalance in the microbial community rather than the mere presence of C. acnes. In fact, a disproportion among the various strains of C. acnes has been linked to acne progression. This shift in understanding moves us away from a simplistic view of "bad bacteria" and towards a nuanced appreciation of the right composition and balance of microbial communities.

Cutibacterium Acnes: The Unexpected Protector

So, what makes C. acnes so special? Here are a few of its superpowers:

1. Colonization Resistance: C. acnes helps keep harmful invaders at bay by breaking down triglycerides in sebum, releasing free fatty acids that possess antimicrobial properties. These acids also contribute to the skin's natural acidic environment, further deterring pathogens.

2. Production of Beneficial Compounds: This bacterium produces antimicrobial peptides and other beneficial metabolites that support skin health.

3. Immune System Modulation: C. acnes plays a vital role in modulating the skin’s immune response, helping to maintain a balanced and healthy complexion.

One of the most exciting discoveries is a protein called RoxP (Radical oxygenase of P. acnes). Think of RoxP as the skin's own superhero, defending against oxidative stress caused by reactive oxygen species (ROS) from environmental factors like UV radiation. RoxP is an antioxidant powerhouse, comparable to renowned antioxidants like Vitamin C and Pomegranate.

Luksha Cosmetics: Embracing Science for Skin Health

At Luksha Cosmetics, we embrace the latest scientific findings to create advanced skincare solutions that maintain the microbial health of your skin. Our Cleansing Oil, a natural oil-based cleanser, effectively removes impurities while preserving your skin’s natural lipids. Additionally, our Eco-Balance Collection perfectly matches the requirements for microbiome-friendly skincare, ensuring your skin maintains the right balance of beneficial bacteria.

The paradigm shift in our understanding of C. acnes underscores a vital message: achieving healthier skin is about maintaining the right composition and balance of the main bacterial families. As we continue to explore the intricate world of the skin microbiome, products that support this balance will become essential allies in our skincare routines.
Next time you think about C. acnes, remember it's not just an acne culprit. It's a complex, multifaceted bacterium that plays a crucial role in keeping your skin healthy and vibrant. Embrace the science, celebrate the balance, and let your skin thrive with the hidden heroes of the microbiome, with a little help from Luksha Cosmetics!

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Debunking Myths: The Truth About "Cruelty-Free" Claim

May 17, 2024

The amount of misleading information circulating in the skincare marketing community is a significant concern for many in the industry. A prime example is the term "cruelty-free," which suggests that some skincare products are tested on animals. The reality, however, is that animal testing on cosmetics has been banned in many regions for decades.

Luksha Cosmetics, a leading skincare brand, frequently receives inquiries from customers about whether their products are tested on animals. The answer is unequivocally no. Luksha Cosmetics does not test its products on animals, nor do they use raw materials that have been tested on animals. This is not just a policy but a legal requirement in many parts of the world. Countries like Canada, the EU, the US, India, Israel, New Zealand, Turkey, the UK, Norway, Brazil, Australia, Taiwan, and South Korea have all banned cosmetic products that involve animal testing.

Furthermore, other countries, including some Asian nations, Argentina, Colombia, and Russia are in the process of passing similar legislation or do not require animal testing. For decades, the cosmetic industry has been shifting away from animal testing, developing alternative and more reliable methods, such as in vitro testing.

In vitro testing, which involves studying cells in a laboratory environment, offers several significant advantages over animal testing. It is more reliable, reproducible, and cost-effective. This method provides more accurate data on how ingredients will interact with human skin, leading to safer and more effective products.

Given these advancements, the notion that some cosmetic products available in regions like the US, the EU or Canada might still be tested on animals is both incorrect and misleading. It’s essential for consumers to be informed about the true state of the industry and the ethical practices that have become standard.

Luksha Cosmetics is committed to transparency and ethical practices. Their dedication to using advanced, non-animal testing methods ensures that they deliver high-quality, safe, and effective products to their customers without compromising their values.

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Discover the Power of Epimedium Sagittatum Extract in Skincare

May 15, 2024

Epimedium sagittatum extract, one of the key ingredients in our Eco-Balance Blemish Defense Serum, is transforming skincare routines for those with blemish-prone skin. Known for its rich blend of prenylated flavonoids, this new, patented ingredient delivers exceptional microbiome-balancing, anti-inflammatory, and antioxidant properties. As we delve into its benefits, it’s clear why this extract is making waves in the beauty industry.

Originating from Central China, Epimedium sagittatum—commonly referred to as “horny goat weed”—has a storied history in traditional Chinese medicine, traditionally used to treat everything from osteoporosis to cardiovascular diseases. Modern science has begun to back up many of these traditional uses, particularly its applications in skincare. The extract’s prowess in combating blemish-causing factors like C. acnes is particularly notable. It not only fights the biofilms that these bacteria produce, which are a major contributor to comedone formation and inflammation, but it also enhances the efficacy of treatments by disrupting these protective barriers.

Clinical trials have shown impressive results: a four-week study revealed that Epimedium sagittatum extract reduced C. acnes-associated coproporphyrin III on the skin by 36%, and decreased sebum production by over 25% in just two weeks. Users also noted visible reductions in redness and inflammation, significantly improving the appearance of blemished skin.

The science behind its effectiveness lies in its ability to modulate several bioactive pathways. It reduces pro-inflammatory cytokines and inhibits key enzymes that contribute to inflammatory processes within the skin. These actions help not only in reducing existing blemishes but also in preventing future outbreaks. The extract's ability to downregulate collagen-degrading MMP genes further aids in protecting against tissue damage and scarring, making it a comprehensive solution for managing blemished and sensitive skin.

As we continue to embrace the synergy between nature and science, Epimedium sagittatum extract exemplifies the cutting-edge advancements in skincare. Our Eco-Balance Blemish Defense Serum, an advanced scientific skincare product specifically designed for acne-prone skin, incorporates this potent natural ingredient among other innovative components. This formula is at the forefront of addressing the complex needs of blemish-prone skin, offering a holistic approach to preventing and treating breakouts, reducing inflammation, and maintaining skin integrity. Harnessing such powerful ingredients ensures that our serum not only treats the symptoms of acne but also nurtures healthier skin overall.

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Unlocking Skin's Resilience: The Power of Multi-Lamellar Structured Skincare

March 29, 2024

 

The quest for radiant, healthy skin often leads us to explore cutting-edge skincare technologies aimed at restoring and fortifying the skin's natural barrier function. Among these advancements, two key technologies stand out, each offering unique benefits in revitalizing the skin's protective shield.

The first technology focuses on enhancing skin moisturization by bolstering the barrier properties that regulate trans epidermal water loss (TEWL). This is achieved through the use of a multi-lamellar structure, mirroring the lipid composition found in the stratum corneum. Comprising a blend of ceramides, fatty acids, and cholesterol, this structure forms a protective layer, significantly improving the skin's barrier function when applied topically. By retaining moisture within the skin's layers, it promotes hydration and helps restore the skin's natural balance.

Meanwhile, the second technology harnesses the power of cellular differentiation to boost the production of epidermal lipids by keratinocytes. This process is crucial for synthesizing and releasing lipids into the extracellular space, where they form a structured multi-lamellar arrangement essential for skin barrier integrity. By activating this cellular pathway, skincare formulations can stimulate lipid production, further reinforcing the skin's protective barrier against external aggressors.

The benefits of incorporating these multi-lamellar structured skincare technologies are manifold. By fortifying the skin's barrier, they effectively inhibit the penetration of harmful substances, such as toxins, allergens, and oxidative agents, through the stratum corneum. This not only reduces the risk of skin irritation and inflammation but also enhances the skin's resilience to environmental stressors. In laboratory studies, regular use of products containing these technologies has shown a marked decrease in skin reactivity among individuals with sensitive skin, highlighting their efficacy in soothing and calming the complexion.

At Luksha Cosmetics, we're committed to harnessing the power of advanced skincare technologies to deliver unparalleled benefits to our customers. Our line of creams, including the Eco-Balance Radiance Cream, Eco-Balance Night Cream, and Moisturizing Cream-Mask, feature a multi-lamellar structure that mimics the skin's natural lipid composition. Gentle yet effective, these formulations are ideal for dry and sensitive skin types, providing superior hydration and protection. By incorporating these innovative products into your skincare routine, you can nurture your skin's barrier function and unleash its inherent radiance and vitality.

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