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News

Skin Dysbiosis: Microbiota Diversity and Its Impact on Skin Health

July 09, 2024

Skin Dysbiosis: Microbiota Diversity and Its Impact on Skin Health

The skin microbiota, an invisible ecosystem of living microorganisms on our skin’s surface, plays a crucial role in maintaining skin health. This bacterial community not only protects our skin from external damage but also interacts with it to ensure proper functioning. When the microbiota is balanced, a condition known as eubiosis is achieved, which is essential for healthy, beautiful skin.

However, various exposome factors, such as overexposure to UV radiation, pollution, and urban lifestyle habits, can disrupt this balance, leading to a state called dysbiosis. Dysbiosis is characterized by an imbalance in the microbial composition, distribution, and metabolic activity on the skin. This imbalance is often observed in skin disorders like atopic dermatitis, acne, and seborrheic dermatitis.

Key Microbiota Species and Their Roles

✔︎ Cutibacterium acnes (C. acnes): Dominating up to 90% of the microbiome in sebum-rich areas like the face and scalp, C. acnes is linked to conditions like acne. A loss of diversity in its phylotypes can lead to exacerbated acne, increased lipogenesis, comedone formation, and inflammation. Certain phylotypes of C. acnes, particularly phylotype lAl, are associated with a more virulent profile in acne-prone skin.

✔︎ Staphylococcus aureus (S. aureus): Known as an opportunistic pathogen, increased populations of S. aureus are related to inflammation, irritation, and conditions like acne, psoriasis, and chronic wounds.

✔︎ Staphylococcus epidermidis (S. epidermidis): This species is a major representative of a healthy skin microbiome and is present across all skin types. It plays a significant role in maintaining an effective skin barrier, wound healing, pathogen defense, immune system modulation, and melanoma prevention.

Prebiotics and Postbiotics: Balancing the Microbiome

Prebiotics, non-digestible food ingredients, stimulate the growth and activity of beneficial microbiota. They are primarily plant-based sugar molecules and oils.

Postbiotics are soluble factors, including products or metabolic byproducts secreted by live bacteria or released after bacterial lysis. These include enzymes, peptides, polysaccharides, cell surface proteins, and organic acids.

Active ingredients and products containing prebiotics and postbiotics can help improve skin conditions by balancing the microbiome. For instance, the Eco-Balance Line by Luksha Cosmetics, formulated specifically for improving the skin microbiome, includes both prebiotics and postbiotics in its science-backed formulas. Topical formulas like these often modulate the skin microbiome by their antibacterial activity against C. acnes and S. aureus, significantly impacting skin health and beauty.

Dysbiosis and Acne-Prone Skin

In acne-prone skin, dysbiosis can lead to the overproduction of sebum, enlarged pores, and worsened acne lesions, redness, and inflammation. The Eco-Balance Blemish Defence Serum by Luksha Cosmetics, featuring Phages and Niacinamide, quickly and effectively improves acne conditions by naturally modulating the skin microbiome with skin-friendly components. 

     In conclusion, understanding the balance of the skin microbiota and utilizing prebiotics and postbiotics can significantly improve skin health, offering promising avenues for treating and managing various skin disorders. The Eco-Balance Line by Luksha Cosmetics exemplifies this approach, providing effective solutions for achieving and maintaining a healthy skin microbiome.

References: 

  1.   Mühlenbruch M, Grossart H-P, Eigemann F, Voss M. Mini-review: Phytoplankton-derived polysaccharides in the marine environment and their interactions with heterotrophic bacteria. Environmental Microbiology. 2018;20(8), 2671-2685
  2.   Gueniche A, Perin, O, Bouslimani A, Landemaine L, Misra N, Cupferman S, Aguilar L, Clavaud C, Chopra T, Khodr A. Advances in Microbiome-Derived Solutions and Methodologies are Founding a New Era in Skin Health and Care. Pathogens. 2022; 11, 121
  3.   Wei Z, Ju Q. Acne and Environmental Factors. In: Acne. Springer International Publishing. 2021; p. 121-9
  4. Dreno B, Dagnelie MA, Khammari A, Corvec (2020). The skin microbiome: A new actor in inflammatory acne. American Journal of Clinical Dermatology. 2020; 21(51), 18-24
  5. Aguilar-Toala JE, Garcia-Varela R, Garcia HS, Mata-Haro V, Gonzalez-Cordova AF, Vallejo-Cordoba B, Hernandez-Mendoza A. Postbiotics: An evolving term within the functional foods field. Trends in Food Science & Technology. 2018; 75, 105-114
  6. Polak K, Jobbagy A, Muszynski T, Wojciechowska K, Fratczak A, Banvölgyi A, Bergler-Czop B, Kiss N. Microbiome Modulation as a Therapeutic Approach in Chronic Skin Diseases. Biomedicines. 2021; 9,1436
  7. Chello C, Conforti C, Dianzani C. Acne Supplementation: Probiotics, Vitamins, and Diet. Acta Dermatovenerologica Croatica. 2021; Nov; 29(4):215-223
  8. Roh M, Han M, Kim D, Chung K. Sebum output as a factor contributing to the size of facial pores: Factors related to enlarged  pores. British Journal of Dermatology. 2006;155(5), 890-894


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