Matrixyl™ 3000 and Argireline® Amplified are two powerhouse peptides in the world of anti-aging skincare, delivering remarkable results for mature skin. Found in our Contouring Multi-Action Cream and Uplifting Eye Cream, these ingredients work together to smooth wrinkles, boost firmness, and refine texture. Backed by cutting-edge science, these peptides dive deep at the molecular level, rejuvenating your skin and restoring a youthful glow. It's no wonder they're key players in any effective anti-aging routine!
Matrixyl™ 3000 is a synergistic blend of palmitoyl tripeptide-1 (C33H65N5O5) and palmitoyl tetrapeptide-7 (C38H68N8O8), both of which are matrikines—messenger peptides capable of regulating cell activities by interacting with their specific receptors. They activate certain genes involved in the process of extracellular matrix renewal and cell proliferation. These mechanisms become weaker and weaker with age.
. These peptides act as signaling molecules that stimulate the skin to repair itself, much like its natural wound-healing process.
Palmitoylation for Enhanced Penetration: The palmitoyl group in Matrixyl™ 3000 (a fatty acid chain) increases the peptide’s lipophilicity, allowing it to penetrate the lipid barrier of the skin more effectively. This deeper penetration ensures the peptides reach the fibroblasts in the dermis, where collagen production takes place.
Collagen Synthesis via MMP Inhibition: Matrixyl™ 3000 works by inhibiting matrix metalloproteinases (MMPs)—enzymes that break down collagen and elastin in the skin. By reducing MMP activity, Matrixyl™ 3000 helps preserve the skin's structural integrity, encouraging fibroblast activity and promoting the synthesis of types I, III, and IV collagen. The result is increased skin firmness and reduced wrinkle depth.
Anti-Inflammatory Properties: Palmitoyl tetrapeptide-7, one of the key components of Matrixyl™ 3000, also reduces the production of pro-inflammatory cytokines, such as interleukin-6 (IL-6), which are elevated during the aging process. By modulating inflammation, Matrixyl™ 3000 helps prevent collagen degradation and soothes mature, sensitive skin.
In Vivo Tests:
28 female volunteers aged from 51 to 72 years, mean age 59. Twice daily application of a cream containing 3% of Matrixyl®3000 for 2 months to one half of the face and the forearm (inner and UV-exposed outer forearm) against placebo.
Argireline® Amplified (acetyl hexapeptide-8: C34H60N14O12S) is a synthetic hexapeptide derived from SNAP-25 (a substrate of the neurotoxin pathway) that works by interrupting the SNARE complex—a set of proteins required for synaptic vesicle release. This inhibition reduces the release of acetylcholine, a neurotransmitter that triggers muscle contractions. As a result, the muscles beneath the skin relax, leading to a reduction in dynamic wrinkles, such as crow’s feet and forehead lines.
SNARE Complex Modulation: The SNARE (Soluble NSF Attachment Protein Receptor) complex plays a crucial role in muscle contraction by facilitating the release of acetylcholine from neurons. By modulating this process, Argireline® Amplified weakens the signal for muscle movement. Unlike invasive treatments like Botox, which completely block muscle contraction, Argireline® Amplified subtly relaxes facial muscles, making it a safer, non-invasive alternative for daily use.
Effectiveness on Dynamic Wrinkles: Dynamic wrinkles, caused by repetitive muscle contractions over time, can deepen as skin loses elasticity with age. Argireline® Amplified specifically targets these expression lines by reducing muscle tension, effectively preventing further deepening of wrinkles.
Peptide Structure and Skin Penetration: Argireline® Amplified is a small peptide that mimics the N-terminal end of SNAP-25, blocking the vesicle fusion necessary for neurotransmitter release. Its size and structure make it effective in penetrating the upper layers of the skin and reaching the targeted neuromuscular junctions to inhibit micro-contractions.
In Vivo Tests: Two panels of 40 and 41 female volunteers between 34-60 years old. Half face application. Expression wrinkles: Evaluated using PRIMOS 3D.
The combination of Matrixyl™ 3000 and Argireline® Amplified provides a multifaceted approach to aging skin by addressing both structural integrity and dynamic wrinkle formation.
Collagen Stimulation + Muscle Relaxation: While Matrixyl™ 3000 works to repair the skin’s extracellular matrix by boosting collagen and elastin production, Argireline® Amplified prevents mechanical stress from muscle contractions that exacerbate wrinkle formation. This dual action helps improve skin firmness while smoothing out expression lines for a more youthful appearance.
Firming and Smoothing: Matrixyl™ 3000 helps restore the skin’s firmness by promoting collagen and hyaluronic acid production, while Argireline® Amplified prevents the mechanical stress caused by muscle movement. Together, they enhance skin elasticity and smoothness.
Hydration and Barrier Support: Matrixyl™ 3000 contributes to improved moisture retention by enhancing hyaluronic acid synthesis, which is essential for mature skin prone to dryness. Argireline® Amplified supports barrier function by reducing mechanical stress on the skin, helping it maintain its resilience.
Matrixyl™ 3000 and Argireline® Amplified are powerful tools in the fight against aging, working together to target wrinkles, loss of firmness, and skin texture. By boosting collagen and relaxing dynamic wrinkles, these peptides offer a comprehensive solution for more youthful, resilient skin.
For those looking to incorporate these potent ingredients into their routine, our Contouring Multi-Action Cream contains both Matrixyl™ 3000 and Argireline® Amplified, providing a double-action effect that lifts and smooths the skin. Additionally, our Uplifting Eye Cream combines Argireline® Amplified with Pentapeptide-18, a peptide known for its synergistic wrinkle-reducing effect when used with Argireline® Amplified. With the highest working concentration of these actives, these products are formulated to deliver visible results, leaving your skin looking firm, smooth, and radiant.
Achieve your best skin with these scientifically-backed ingredients and experience the transformation firsthand.
References:
1. Lintner, K., & Peschard, O. (2000). Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International Journal of Cosmetic Science, 22(3), 207–218.
2. Schagen, S. K. (2017). Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetic Dermatology, 16(3), 142-149.
3. Blanes-Mira, C., Clemente, J., Jodas, G., et al. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science, 24(5), 303–310.
4. Bos, J. D., & Meinardi, M. M. (2000). The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Experimental Dermatology, 9(3), 165–169.
5. Fields, K., Falla, T. J., Rodan, K., & Bush, L. (2009). Topical argireline in the treatment of lines and wrinkles: A randomized controlled trial. Journal of Clinical Aesthetic Dermatology, 2(5), 28-34
