The science of anti-aging skincare has advanced far beyond “hydrate and hope.” Today’s most promising technologies work in concert with the skin’s own biology — and few actives illustrate this better than bioactive peptides.
Two peptides in particular — Acetyl Hexapeptide-8 and Tetrapeptide-21 — are redefining how we address wrinkles, firmness, and structural fatigue, especially in mature, fatigued, or sensitive skin.
Acetyl Hexapeptide-8, often referred to as Argireline®, is a peptide complex composed of six amino acids. Its primary mechanism targets SNARE complex proteins involved in neurotransmitter release at the neuromuscular junction. By inhibiting this release, it reduces muscle contraction, softening dynamic expression lines like crow’s feet and forehead wrinkles.
Before use 15 days
Unlike injectable neuromodulators (such as botulinum toxin), Acetyl Hexapeptide-8 acts locally and gradually, providing a non-invasive, cumulative effect with excellent tolerability. Clinical studies report up to a 30% wrinkle depth reduction in 15-30 days with regular use.
This makes it ideal for:
Skin sensitive to aggressive treatments
Early signs of expression wrinkles
Users seeking preventative care without injections
While Acetyl Hexapeptide-8 reduces muscle-induced wrinkles, Tetrapeptide-21 takes a structural approach. This peptide sequence is derived from signal peptides known to stimulate dermal fibroblasts, the cells responsible for producing collagen, elastin, and hyaluronic acid.
Tetrapeptide-21 has been shown to:
Boost collagen I and III synthesis
Increase skin elasticity and density
Reduce wrinkle depth and roughness
What sets it apart is its ability to mimic the skin’s natural signaling during repair — enhancing the skin’s own regenerative capacity without overstimulation. Clinical use results in firmer, more elastic skin with improved texture and tone over time.
Used together, these two peptides address both the surface tension and the underlying structure of aging skin:
Acetyl Hexapeptide-8 helps relax fine lines
Tetrapeptide-21 rebuilds the dermal matrix for long-term strength and elasticity
This creates a two-level anti-aging approach: immediate smoothing + cumulative rejuvenation.
In Cellévra Lift Cream, these two peptides are paired with 3-Glyceryl Ascorbate — a stabilized, water-soluble form of Vitamin C with antioxidant and collagen-boosting properties.
Combined, these three actives provide a multidimensional rejuvenation strategy — relax, rebuild, and protect — all in a lamellar cream base that mimics the skin’s lipid barrier for better delivery and lower irritation.
Modern anti-aging skincare isn't about overwhelming the skin with actives. It’s about precision engineering — using clinically backed molecules, in optimized delivery systems, to support what the skin already knows how to do.
The combination of Acetyl Hexapeptide-8, Tetrapeptide-21, and 3-Glyceryl Ascorbate in Cellévra Lift Cream represents this new generation of thoughtful, science-driven care — designed to restore vitality, resilience, and clarity to aging skin, gently and intelligently.
Blanes-Mira C, et al. A synthetic hexapeptide (Argireline®) with antiwrinkle activity. Int J Cosmet Sci. 2002.
Lintner K, et al. Cosmetic benefits of tetrapeptide-21: collagen stimulation. Dermato-Endocrinology. 2012.
Hiroshi T, et al. Skin benefits of glyceryl ascorbate: A novel vitamin C derivative. J Cosmet Dermatol. 2017.
Rawlings AV, Harding CR. Moisturization and skin barrier function. Dermatol Ther. 2004.
